The Africa Climate and Health Alliance (ACHA) recognizes that climate change is not just an environmental crisis but also a profound public health challenge, with Africa at the frontline of its impacts. As we prepare for the 29th United Nations Climate Change Conference (COP29) in Baku, Azerbaijan, ACHA presents a bold and urgent Call to Action for a climate agenda that puts human health, climate justice, and equity at the heart of decision-making. African nations contribute the least to global greenhouse gas emissions but suffer disproportionately from the consequences of climate change—rising temperatures, extreme weather events, and food and water insecurity—resulting in devastating health outcomes.