The youth of Africa anticipate the UNGA High-level Meeting on AMR to deliver ambitious commitments that accelerate equitable efforts towards curbing Antimicrobial Resistance (AMR) globally. AMR disproportionately impacts communities in the African continent which also faces a large burden of infectious diseases compared to other parts of the world (except for Asia). The diverse cultural values, prevalence of infectious diseases (including Neglected Tropical Diseases), weak healthcare systems, fragmented supply chains and economic dimensions impose distinct challenges in the fight against AMR. It is therefore imperative to recognize that the future of Africa depends on, among other developmental issues, effectively addressing the threat of AMR, as its impact extends to the economic development and social stability of the continent.